Language: English


COVID-19 Vaccines

Updated 22 June 2021

English version last updated on 22 June 2021 to reflect 15 June 2021 SAGE interim recommendations on the Pfizer/BionTech COVID-19 vaccine.

Is there a vaccine for COVID-19?

Yes there are now several vaccines that are in use. The first mass vaccination programme started in early December 2020 and the number of vaccination doses administered is updated on a daily basis here. At least 13 different vaccines (across 4 platforms) have been administered.

The Pfizer/BioNtech Comirnaty vaccine was listed for WHO Emergency Use Listing (EUL) on 31 December 2020. The SII/Covishield and AstraZeneca/AZD1222 vaccines (developed by AstraZeneca/Oxford and manufactured by the State Institute of India and SK Bio respectively) were given EUL on 16 February. The Janssen/Ad26.COV 2.S developed by Johnson & Johnson, was listed for EUL on 12 March 2021. The Moderna COVID-19 vaccine (mRNA 1273) was listed for EUL on 30 April 2021 and the Sinopharm COVID-19 vaccine was listed for EUL on 7 May 2021. The Sinopharm vaccine is produced by Beijing Bio-Institute of Biological Products Co Ltd, subsidiary of China National Biotec Group (CNBG). The Sinovac-CoronaVac was listed for EUL on 1 June 2021.

For further information, see here.

WHO is on track to EUL other vaccine products through June. 

The products and progress in regulatory review by WHO is provided by WHO and updated regularly. The document is provided here.

Once vaccines are demonstrated to be safe and efficacious, they must be authorized by national regulators, manufactured to exacting standards, and distributed. WHO is working with partners around the world to help coordinate key steps in this process, including to facilitate equitable access to safe and effective COVID-19 vaccines for the billions of people who will need them. More information about COVID-19 vaccine development is available  here.

When will COVID-19 vaccines be ready for distribution?

The first COVID-19 vaccines have already begun to be introduced in countries. Before COVID-19 vaccines can be delivered:

  • The vaccines must be proven safe and effective in large (phase III) clinical trials.  Some COVID-19 vaccine candidates have completed their phase III trials, and many other potential vaccines are being developed.
  • Independent reviews of the efficacy and safety evidence is required for each vaccine candidate, including regulatory review and approval in the country where the vaccine is manufactured, before WHO considers a vaccine candidate for prequalification. Part of this process also involves the Global Advisory Committee on Vaccine Safety.
  • In addition to review of the data for regulatory purposes, the evidence must also be reviewed for the purpose of policy recommendations on how the vaccines should be used.
  • An external panel of experts convened by WHO, called the Strategic Advisory Group of Experts on Immunization (SAGE), analyzes the results from clinical trials, along with evidence on the disease, age groups affected, risk factors for disease, programmatic use, and other information. SAGE then recommends whether and how the vaccines should be used.
  • Officials in individual countries decide whether to approve the vaccines for national use and develop policies for how to use the vaccines in their country based on the WHO recommendations.
  • The vaccines must be manufactured in large quantities, which is a major and unprecedented challenge – all the while continuing to produce all the other important life-saving vaccines already in use.
  • As a final step, all approved vaccines will require distribution through a complex logistical process, with rigorous stock management and temperature control.

WHO is working with partners around the world to accelerate every step of this process, while also ensuring the highest safety standards are met. More information is available here.

Will COVID-19 vaccines provide long-term protection?

Because COVID vaccines have only been developed in the past months, it’s too early to know the duration of protection of COVID-19 vaccines. Research is ongoing to answer this question. However, it’s encouraging that available data suggest that most people who recover from COVID-19 develop an immune response that provides at least some period of protection against reinfection – although we’re still learning how strong this protection is, and how long it lasts.

How quickly could COVID-19 vaccines stop the pandemic?

The impact of COVID-19 vaccines on the pandemic will depend on several factors. These include the effectiveness of the vaccines; how quickly they are approved, manufactured, and delivered; the possible development of other variants and how many people get vaccinated

Whilst trials have shown several COVID-19 vaccines to have high levels of efficacy, like all other vaccines, COVID-19 vaccines will not be 100% effective. WHO is working to help ensure that approved vaccines are as effective as possible, so they can have the greatest impact on the pandemic.

What types of COVID-19 vaccines are being developed? How would they work?

Scientists around the world are developing many potential vaccines for COVID-19. These vaccines are all designed to teach the body’s immune system to safely recognize and block the virus that causes COVID-19.

Several different types of potential vaccines for COVID-19 are in development, including:

  • Inactivated or weakened virus vaccines, which use a form of the virus that has been inactivated or weakened so it doesn’t cause disease, but still generates an immune response.
  • Protein-based vaccines, which use harmless fragments of proteins or protein shells that mimic the COVID-19 virus to safely generate an immune response.
  • Viral vector vaccines, which use a safe virus that cannot cause disease but serves as a platform to produce coronavirus proteins to generate an immune response.
  • RNA and DNA vaccines, a cutting-edge approach that uses genetically engineered RNA or DNA to generate a protein that itself safely prompts an immune response.

For more information about all COVID-19 vaccines in development, see this WHO publication, which is being updated regularly. 

Will other vaccines help protect me from COVID-19?

Currently, there is no evidence that any other vaccines, apart from those specifically designed for the SARS-Cov-2 virus,  will protect against COVID-19.

However, scientists are studying whether some existing vaccines – such as the Bacille Calmette-Guérin (BCG) vaccine, which is used to prevent tuberculosis – are also effective for COVID-19. WHO will evaluate evidence from these studies when available.

What are the benefits of getting vaccinated?

The COVID-19 vaccines produce protection against the disease, as a result of developing an immune response to the SARS-Cov-2 virus.  Developing immunity through vaccination means there is a reduced risk of developing the  illness and its consequences. This immunity helps you fight the virus if exposed. Getting vaccinated may also protect people around you, because if you are protected from getting infected and from disease, you are less likely to infect someone else. This is particularly important to protect people at increased risk for severe illness from COVID-19, such as healthcare providers, older or elderly adults, and people with other medical conditions.

Who should get the COVID-19 vaccines?

The COVID-19 vaccines are safe for most people 18 years and older, including those with pre-existing conditions of any kind, including auto-immune disorders. These conditions include: hypertension, diabetes, asthma, pulmonary, liver and kidney disease, as well as chronic infections that are stable and controlled. If supplies are limited in your area, discuss your situation with your care provider if you:

  • Have a compromised immune system
  • Are pregnant or nursing your baby
  • Have a history of severe allergies, particularly to a vaccine (or any of the ingredients in the vaccine)
  • Are severely frail 

Can we stop taking precautions after being vaccinated?

Vaccination protects you from getting seriously ill and dying from COVID-19. For the first fourteen days after getting a vaccination, you do not have significant levels of protection, then it increases gradually. For a single dose vaccine, immunity will generally occur two weeks after vaccination. For two-dose vaccines, both doses are needed to achieve the highest level of immunity possible. 

While a COVID-19 vaccine will protect you from serious illness and death, we are still learning about the extent to which it keeps you from being infected and passing the virus on to others (transmission). The data that is emerging from countries is showing that the vaccines that are currently in use are protecting against severe disease and hospitalization. However, no vaccine is 100% effective and breakthrough infections are regrettable, but to be expected.

The current evidence shows that vaccines provide some protection from infection and transmission, but that protection is less than that for serious illness and death. We are still learning also about the variants of concern and whether the vaccines are as protective against these strains as the non-variant virus.  For these reasons, and while many of those in the community may not yet be vaccinated, maintaining other prevention measures is important especially in communities where SARS CoV-2 circulation is significant. To help keep you and others safe, and while efforts continue to reduce viral transmission and ramp up vaccine coverage, you should continue to maintain at least a 1-metre distance from others, cover a cough or sneeze in your elbow, clean your hands frequently and wear a mask, particularly in enclosed, crowded or poorly ventilated spaces. Always follow guidance from local authorities based on the situation and risk where you live.

Can I have the second dose with a different vaccine than the first dose?

Clinical trials in some countries are looking at whether you can have a first dose from one vaccine and a second dose from a different vaccine. There isn't enough data yet to recommend this type of combination. 

Can the COVID-19 vaccine cause a positive test result for the disease, such as for a PCR or antigen test?

No, the COVID-19 vaccine will not cause a positive test result for a COVID-19 PCR or antigen laboratory test. This is because the tests check for active disease and not whether an individual is immune or not. However, because the COVID-19 vaccine prompts an immune response, it may be possible to test positive in an antibody (serology) test that measures COVID-19 immunity in an individual.

Should I be vaccinated if I have had COVID-19?

Even if you have already had COVID-19, you should be vaccinated when it is offered to you. The protection that someone gains from having COVID-19 will vary from person to person, and we also don’t know how long natural immunity might last. 

Is the vaccine safe for children?

Vaccines are usually tested in adults first, and only later assessed in children when safety has been proven in adults, because children are still developing and growing. COVID-19 has also been a more serious and dangerous disease among older people. Now that the vaccines have been determined to be safe for adults, they are being studied in children.

WHO's Strategic Advisory Group of Experts (SAGE) has concluded that the Pfizer/BionTech vaccine is suitable for use by people aged 12 years and above. Children aged between 12 and 15 who are at higher risk of severe COVID-19 may be offered this vaccine alongside other priority groups for vaccination. Vaccine trials for children are ongoing and WHO will update its recommendations when the evidence or epidemiological situation justifies a change in policy.

While the supply of vaccines is limited, the ongoing priority is to vaccinate those most at risk of serious illness who still have not been vaccinated in many parts of the world: older people, those with chronic health conditions, and health workers.

Most children are at low risk of serious disease and vaccinating them is primarily about reducing transmission, which can also be achieved through public health measures, including: physically distancing from others, cleaning hands frequently, sneezing and coughing into their elbow, wearing a mask if age appropriate and avoiding crowded, poorly ventilated spaces.

Do the vaccines protect against variants?

More studies are needed to assess the effectiveness of the current COVID vaccines against the variants. A growing body of data suggests that most vaccines stimulate enough immunity to retain substantial efficacy against most variants, especially for severe disease, hospitalization, and death. The impact of the variants on efficacy against mild disease and against infection without disease is more impacted than for the more severe outcomes.

The reason vaccines substantially retain protection against disease is likely related to the broad immune response they induce, which means that virus changes or mutations are unlikely to make vaccines completely ineffective. If any of these vaccines become less effective against one or more variants, it will likely be possible to change the composition of the vaccines to protect against these variants, however this will take time and additional data to fully evaluate. Data continues to be collected and analysed on new variants of the COVID-19 virus. WHO will update its guidance when more details are known about the impact of specific variants on specific vaccines.  WHO’s SAGE is reviewing this evidence on a regular basis.

While we are learning more, we need to do everything possible to stop the spread of the virus in order to prevent mutations that may reduce the performance of existing vaccines. This means staying at least 1 metre away from others, covering a cough or sneezing in your elbow, frequently cleaning your hands, wearing a mask and avoiding crowded, poorly ventilated rooms or opening a window. 

Does the vaccine cause different side effects in men and women? Does age have an impact?

The effect of the COVID-19 vaccine varies from person to person, like it does for most vaccines. As more people get vaccinated, we may be able to determine patterns. This information continues to be collected and will be shared, but for now, we cannot anticipate who may have side effects.

Does having side effects mean that the vaccine is working? What does having no side effects mean?

The vaccine stimulates your immune system to protect you from the virus. This process can sometimes cause side effects like fever, chills or headache, but not everyone experiences this. The presence or magnitude of the reaction you may have vaccination does not predict or reflect your immune response to the vaccine. You do not have to have side effects in order to be protected. 

Should we eat or drink differently the day or two after getting vaccinated?

The effectiveness of the vaccine is not dependent on any food or drink before or after taking the vaccine.